Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis
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Sjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis
We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephritis with mesangial deposits, subendothelial deposits, and subepithelial deposits. Immunofluoresc...
متن کاملMembranoproliferative Glomerulonephritis
Membranoproliferative glomerulonephritis (MPGN) refers to glomerular pathology in which there is thickening of the capillary wall together with mesangial expansion. In this article we firstly review the pathological features of MPGN and discuss how advances in our understanding of the association between abnormalities in the regulation of complement and MPGN have revealed limitations in the his...
متن کاملMembranoproliferative glomerulonephritis.
Glomerulonephritis (GN) encompasses a wide variety of primary and secondary diseases that cause injury to the functioning unit of the kidney, the glomerulus. The many classifications of GN sometimes lead to confusion. This case study describes an individual with membranoproliferative GN and includes discussion of classification, treatment, and prognosis of this disease.
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Membranous glomerulonephritis is characterised by accumulation of immune complexes on the outside of the glomerular basement membrane. This leads to development of projections of the membrane adjacent to the deposits which eventually become incorporated into the membrane. In about 20% of cases the disease occurs in association with another condition such as SLE, cancer or drug exposure. The rem...
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Atypical hemolytic uremic syndrome (aHUS) associated with membranoproliferative glomerulonephritis (MPGN) is an uncommon clinical presentation, especially in children. We report a 8-year-old-boy who presented like aHUS but the kidney biopsy showed MPGN type 1.
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ژورنال
عنوان ژورنال: Case Reports in Nephrology and Dialysis
سال: 2016
ISSN: 2296-9705
DOI: 10.1159/000452298